home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 275.2 KB |
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MacOS 8.1
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Win98
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DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000490| 00 00 38 32 00 00 00 01 | 21 85 03 00 ca 0a 00 00 |..82....|!.......|
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|000004b0| 00 00 00 01 5c 9a 03 00 | 61 0e 00 00 38 35 00 00 |....\...|a...85..|
|000004c0| 00 01 bd a8 03 00 29 0a | 00 00 38 36 00 00 00 01 |......).|..86....|
|000004d0| e6 b2 03 00 72 09 00 00 | 38 37 00 00 00 01 58 bc |....r...|87....X.|
|000004e0| 03 00 80 0a 00 00 38 38 | 00 00 00 01 d8 c6 03 00 |......88|........|
|000004f0| 18 0d 00 00 38 39 00 00 | 00 01 f0 d3 03 00 f2 0c |....89..|........|
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|00000510| 39 31 00 00 00 01 7a eb | 03 00 23 0d 00 00 39 32 |91....z.|..#...92|
|00000520| 00 00 00 01 9d f8 03 00 | 38 0b 00 00 39 33 00 00 |........|8...93..|
|00000530| 00 01 d5 03 04 00 77 0a | 00 00 39 34 00 00 00 01 |......w.|..94....|
|00000540| 4c 0e 04 00 da 08 00 00 | 39 35 00 00 00 01 26 17 |L.......|95....&.|
|00000550| 04 00 eb 0c 00 00 39 36 | 00 00 00 01 11 24 04 00 |......96|.....$..|
|00000560| 86 0b 00 00 39 37 00 00 | 00 01 97 2f 04 00 25 0b |....97..|.../..%.|
|00000570| 00 00 39 38 00 00 00 01 | bc 3a 04 00 62 09 00 00 |..98....|.:..b...|
|00000580| 39 39 00 00 00 01 1e 44 | 04 00 de 08 00 00 00 00 |99.....D|........|
|00000590| 00 00 00 00 fc 4c 04 00 | 00 00 00 00 24 55 6e 69 |.....L..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 39 38 30 30 7d |que_ID{Y|RB09800}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 53 75 72 76 65 79 20 |..$Title|{Survey |
|000005c0| 4d 65 74 68 6f 64 20 66 | 6f 72 20 50 6f 73 74 2d |Method f|or Post-|
|000005d0| 4d 61 72 6b 65 74 69 6e | 67 20 44 72 75 67 20 53 |Marketin|g Drug S|
|000005e0| 75 72 76 65 69 6c 6c 61 | 6e 63 65 3a 20 20 41 20 |urveilla|nce: A |
|000005f0| 44 65 6d 6f 6e 73 74 72 | 61 74 69 6f 6e 7d 0d 0a |Demonstr|ation}..|
|00000600| 24 41 75 74 68 6f 72 7b | 4d 65 6c 6c 69 6e 67 65 |$Author{|Mellinge|
|00000610| 72 2c 20 47 44 0d 0a 42 | 61 6c 74 65 72 2c 20 4d |r, GD..B|alter, M|
|00000620| 42 0d 0a 41 62 72 61 6d | 6f 77 69 74 7a 2c 20 53 |B..Abram|owitz, S|
|00000630| 0d 0a 53 63 68 61 66 66 | 65 72 2c 20 43 42 0d 0a |..Schaff|er, CB..|
|00000640| 42 65 72 6e 73 74 65 69 | 6e 2c 20 4c 52 7d 0d 0a |Bernstei|n, LR}..|
|00000650| 24 41 66 66 69 6c 69 61 | 74 69 6f 6e 7b 49 6e 73 |$Affilia|tion{Ins|
|00000660| 74 20 66 6f 72 20 52 65 | 73 65 61 72 63 68 20 69 |t for Re|search i|
|00000670| 6e 20 53 6f 63 69 61 6c | 20 42 65 68 61 76 69 6f |n Social| Behavio|
|00000680| 72 2c 20 4f 61 6b 6c 61 | 6e 64 2c 20 43 61 6c 69 |r, Oakla|nd, Cali|
|00000690| 66 3b 20 4e 61 74 6c 20 | 49 6e 73 74 20 6f 66 20 |f; Natl |Inst of |
|000006a0| 4d 65 6e 74 61 6c 20 48 | 65 61 6c 74 68 2c 20 52 |Mental H|ealth, R|
|000006b0| 6f 63 6b 76 69 6c 6c 65 | 2c 20 4d 64 3b 20 55 6e |ockville|, Md; Un|
|000006c0| 69 76 20 6f 66 20 43 61 | 6c 69 66 6f 72 6e 69 61 |iv of Ca|lifornia|
|000006d0| 2c 20 44 61 76 69 73 3b | 20 55 6e 69 76 20 6f 66 |, Davis;| Univ of|
|000006e0| 20 43 61 6c 69 66 6f 72 | 6e 69 61 2c 20 53 61 6e | Califor|nia, San|
|000006f0| 20 46 72 61 6e 63 69 73 | 63 6f 7d 0d 0a 24 4a 6f | Francis|co}..$Jo|
|00000700| 75 72 6e 61 6c 7b 4a 20 | 43 6c 69 6e 20 50 73 79 |urnal{J |Clin Psy|
|00000710| 63 68 6f 70 68 61 72 6d | 61 63 6f 6c 7d 0d 0a 24 |chopharm|acol}..$|
|00000720| 56 6f 6c 75 6d 65 7b 38 | 7d 0d 0a 24 50 61 67 65 |Volume{8|}..$Page|
|00000730| 7b 31 36 38 2d 31 37 36 | 7d 0d 0a 24 44 61 74 65 |{168-176|}..$Date|
|00000740| 7b 4a 75 6e 65 20 31 39 | 38 38 7d 0d 0a 24 59 42 |{June 19|88}..$YB|
|00000750| 56 6f 6c 7b 31 39 39 30 | 20 59 65 61 72 20 42 6f |Vol{1990| Year Bo|
|00000760| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|00000770| 70 79 7d 0d 0a 24 43 68 | 61 70 74 65 72 7b 31 2d |py}..$Ch|apter{1-|
|00000780| 31 7d 0d 0a 24 59 42 45 | 64 69 74 6f 72 7b 44 72 |1}..$YBE|ditor{Dr|
|00000790| 73 2e 20 48 6f 6c 6c 69 | 73 74 65 72 20 61 6e 64 |s. Holli|ster and|
|000007a0| 20 4c 61 73 61 67 6e 61 | 7d 0d 0a 24 54 61 62 6c | Lasagna|}..$Tabl|
|000007b0| 65 7b 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |e{}..$Co|mmentato|
|000007c0| 72 7b 4c 2e 20 20 4c 61 | 73 61 67 6e 61 2c 20 4d |r{L. La|sagna, M|
|000007d0| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|000007e0| 74 20 28 63 29 20 59 65 | 61 72 62 6f 6f 6b 20 4d |t (c) Ye|arbook M|
|000007f0| 65 64 69 63 61 6c 20 50 | 75 62 6c 69 73 68 65 72 |edical P|ublisher|
|00000800| 73 2c 20 49 6e 63 2e 2c | 20 31 39 39 30 0d 0a 0d |s, Inc.,| 1990...|
|00000810| 0a 31 39 39 30 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1990 Ye|ar Book |
|00000820| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 20 |of Drug |Therapy |
|00000830| 28 52 29 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 31 |(R)....C|hapter 1|
|00000840| 2d 2d 47 65 6e 65 72 61 | 6c 20 49 6e 66 6f 72 6d |--Genera|l Inform|
|00000850| 61 74 69 6f 6e 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |ation...|.-------|
|00000860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000890| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008a0| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 53 75 72 76 65 79 20 |-------.|.Survey |
|000008b0| 4d 65 74 68 6f 64 20 66 | 6f 72 20 50 6f 73 74 2d |Method f|or Post-|
|000008c0| 4d 61 72 6b 65 74 69 6e | 67 20 44 72 75 67 20 53 |Marketin|g Drug S|
|000008d0| 75 72 76 65 69 6c 6c 61 | 6e 63 65 3a 20 20 41 20 |urveilla|nce: A |
|000008e0| 44 65 6d 6f 6e 73 74 72 | 61 74 69 6f 6e 0d 0a 0d |Demonstr|ation...|
|000008f0| 0a 4d 65 6c 6c 69 6e 67 | 65 72 20 47 44 3b 20 42 |.Melling|er GD; B|
|00000900| 61 6c 74 65 72 20 4d 42 | 3b 20 41 62 72 61 6d 6f |alter MB|; Abramo|
|00000910| 77 69 74 7a 20 53 3b 20 | 53 63 68 61 66 66 65 72 |witz S; |Schaffer|
|00000920| 20 43 42 3b 20 42 65 72 | 6e 73 74 65 69 6e 20 4c | CB; Ber|nstein L|
|00000930| 52 0d 0a 28 49 6e 73 74 | 20 66 6f 72 20 52 65 73 |R..(Inst| for Res|
|00000940| 65 61 72 63 68 20 69 6e | 20 53 6f 63 69 61 6c 20 |earch in| Social |
|00000950| 42 65 68 61 76 69 6f 72 | 2c 20 4f 61 6b 6c 61 6e |Behavior|, Oaklan|
|00000960| 64 2c 20 43 61 6c 69 66 | 3b 0d 0a 4e 61 74 6c 20 |d, Calif|;..Natl |
|00000970| 49 6e 73 74 20 6f 66 20 | 4d 65 6e 74 61 6c 20 48 |Inst of |Mental H|
|00000980| 65 61 6c 74 68 2c 20 52 | 6f 63 6b 76 69 6c 6c 65 |ealth, R|ockville|
|00000990| 2c 20 4d 64 3b 20 55 6e | 69 76 20 6f 66 20 43 61 |, Md; Un|iv of Ca|
|000009a0| 6c 69 66 6f 72 6e 69 61 | 2c 20 44 61 76 69 73 3b |lifornia|, Davis;|
|000009b0| 0d 0a 55 6e 69 76 20 6f | 66 20 43 61 6c 69 66 6f |..Univ o|f Califo|
|000009c0| 72 6e 69 61 2c 20 53 61 | 6e 20 46 72 61 6e 63 69 |rnia, Sa|n Franci|
|000009d0| 73 63 6f 29 0d 0a 4a 20 | 43 6c 69 6e 20 50 73 79 |sco)..J |Clin Psy|
|000009e0| 63 68 6f 70 68 61 72 6d | 61 63 6f 6c 20 38 3a 31 |chopharm|acol 8:1|
|000009f0| 36 38 2d 31 37 36 2c 20 | 4a 75 6e 65 20 31 39 38 |68-176, |June 198|
|00000a00| 38 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |8..-----|--------|
|00000a10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a50| 2d 0d 0a 0d 0a 41 62 73 | 74 72 61 63 74 0d 0a 0d |-....Abs|tract...|
|00000a60| 0a 20 20 20 20 20 50 6f | 73 74 6d 61 72 6b 65 74 |. Po|stmarket|
|00000a70| 69 6e 67 20 64 72 75 67 | 20 73 75 72 76 65 69 6c |ing drug| surveil|
|00000a80| 6c 61 6e 63 65 20 28 50 | 4d 44 53 29 20 6f 66 66 |lance (P|MDS) off|
|00000a90| 65 72 73 20 74 68 65 20 | 6f 70 70 6f 72 74 75 6e |ers the |opportun|
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|00000ab0| 66 69 63 61 63 79 20 61 | 6e 64 20 73 61 66 65 74 |ficacy a|nd safet|
|00000ac0| 79 20 75 6e 64 65 72 20 | 63 6f 6e 64 69 74 69 6f |y under |conditio|
|00000ad0| 6e 73 20 74 68 61 74 20 | 77 65 72 65 20 61 62 73 |ns that |were abs|
|00000ae0| 65 6e 74 20 6f 72 20 65 | 78 63 6c 75 64 65 64 20 |ent or e|xcluded |
|00000af0| 69 6e 20 74 68 65 0d 0a | 69 6e 69 74 69 61 6c 20 |in the..|initial |
|00000b00| 63 6c 69 6e 69 63 61 6c | 20 74 72 69 61 6c 73 2e |clinical| trials.|
|00000b10| 20 20 54 68 65 20 72 65 | 73 75 6c 74 73 20 66 72 | The re|sults fr|
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|00000b40| 69 63 68 20 61 0d 0a 63 | 6f 6d 6d 75 6e 69 74 79 |ich a..c|ommunity|
|00000b50| 20 73 75 72 76 65 79 20 | 6d 65 74 68 6f 64 20 77 | survey |method w|
|00000b60| 61 73 20 61 70 70 6c 69 | 65 64 20 74 6f 20 61 20 |as appli|ed to a |
|00000b70| 50 4d 44 53 20 77 65 72 | 65 20 65 76 61 6c 75 61 |PMDS wer|e evalua|
|00000b80| 74 65 64 2e 0d 0a 20 20 | 20 20 20 52 65 70 72 65 |ted... | Repre|
|00000b90| 73 65 6e 74 61 74 69 76 | 65 20 73 61 6d 70 6c 65 |sentativ|e sample|
|00000ba0| 73 20 6f 66 20 6f 75 74 | 70 61 74 69 65 6e 74 73 |s of out|patients|
|00000bb0| 20 74 72 65 61 74 65 64 | 20 77 69 74 68 20 74 72 | treated| with tr|
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|00000c40| 74 20 68 6f 6d 65 20 6f | 72 20 62 79 20 70 68 6f |t home o|r by pho|
|00000c50| 6e 65 2e 20 20 4c 61 79 | 20 69 6e 74 65 72 76 69 |ne. Lay| intervi|
|00000c60| 65 77 65 72 73 0d 0a 74 | 72 61 69 6e 65 64 20 74 |ewers..t|rained t|
|00000c70| 6f 20 75 73 65 20 61 20 | 64 65 74 61 69 6c 65 64 |o use a |detailed|
|00000c80| 20 69 6e 74 65 72 76 69 | 65 77 20 73 63 68 65 64 | intervi|ew sched|
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|00000ca0| 65 20 64 61 74 61 2e 20 | 20 54 68 65 20 64 65 67 |e data. | The deg|
|00000cb0| 72 65 65 0d 0a 74 6f 20 | 77 68 69 63 68 20 70 72 |ree..to |which pr|
|00000cc0| 65 64 69 63 74 65 64 20 | 6f 75 74 63 6f 6d 65 73 |edicted |outcomes|
|00000cd0| 20 66 6f 72 20 74 68 65 | 20 32 20 77 65 6c 6c 2d | for the| 2 well-|
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|00000cf0| 73 73 65 73 20 6d 61 74 | 63 68 65 64 0d 0a 6f 62 |sses mat|ched..ob|
|00000d00| 73 65 72 76 65 64 20 6f | 75 74 63 6f 6d 65 73 20 |served o|utcomes |
|00000d10| 77 61 73 20 64 65 74 65 | 72 6d 69 6e 65 64 2e 20 |was dete|rmined. |
|00000d20| 20 54 77 6f 20 63 6f 6e | 74 72 61 73 74 20 67 72 | Two con|trast gr|
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|00000d40| 65 6e 74 20 70 65 72 69 | 6f 64 73 2c 0d 0a 61 6e |ent peri|ods,..an|
|00000d50| 64 20 36 20 6b 65 79 20 | 73 79 6d 70 74 6f 6d 73 |d 6 key |symptoms|
|00000d60| 20 6d 65 61 73 75 72 65 | 73 20 77 65 72 65 20 69 | measure|s were i|
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|00002880| 20 31 39 38 38 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1988..-|--------|
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|000028a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000028b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000028c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002c00| 24 32 2c 37 33 33 20 28 | 46 69 67 20 31 2d 31 29 |$2,733 (|Fig 1-1)|
|00002c10| 2e 20 20 54 68 65 20 61 | 76 65 72 61 67 65 0d 0a |. The a|verage..|
|00002c20| 72 65 64 75 63 74 69 6f | 6e 20 69 6e 20 74 68 65 |reductio|n in the|
|00002c30| 20 63 6f 73 74 20 6f 66 | 20 61 6e 74 69 62 69 6f | cost of| antibio|
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|00002c70| 76 65 72 61 67 65 20 6d | 6f 6e 74 68 6c 79 20 61 |verage m|onthly a|
|00002c80| 6d 6f 75 6e 74 20 73 61 | 76 65 64 2c 20 24 32 2c |mount sa|ved, $2,|
|00002c90| 38 35 30 20 28 33 37 2e | 33 25 29 20 63 61 6d 65 |850 (37.|3%) came|
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|00002d10| 73 75 6c 74 61 6e 74 2e | 20 20 54 68 65 20 72 65 |sultant.| The re|
|00002d20| 73 74 20 77 61 73 20 73 | 61 76 65 64 20 62 79 20 |st was s|aved by |
|00002d30| 74 68 65 20 68 6f 75 73 | 65 20 73 74 61 66 66 2e |the hous|e staff.|
|00002d40| 20 20 54 68 65 20 69 6d | 70 61 63 74 20 6f 66 0d | The im|pact of.|
|00002d50| 0a 74 68 69 73 20 73 79 | 73 74 65 6d 20 6f 6e 20 |.this sy|stem on |
|00002d60| 74 72 65 61 74 6d 65 6e | 74 20 6f 75 74 63 6f 6d |treatmen|t outcom|
|00002d70| 65 73 20 72 65 6d 61 69 | 6e 73 20 74 6f 20 62 65 |es remai|ns to be|
|00002d80| 20 65 76 61 6c 75 61 74 | 65 64 2e 0d 0a 0d 0a 50 | evaluat|ed.....P|
|00002d90| 6f 73 74 2d 43 6f 6d 6d | 65 6e 74 0d 0a 0d 0a 20 |ost-Comm|ent.... |
|00002da0| 20 20 20 20 4e 65 77 20 | 61 6e 74 69 62 69 6f 74 | New |antibiot|
|00002db0| 69 63 73 20 6b 65 65 70 | 20 62 65 69 6e 67 20 64 |ics keep| being d|
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|00002dd0| 20 77 65 6c 63 6f 6d 65 | 20 61 64 64 69 74 69 6f | welcome| additio|
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|00002df0| 63 68 61 6c 6c 65 6e 67 | 69 6e 67 20 66 69 67 68 |challeng|ing figh|
|00002e00| 74 20 61 67 61 69 6e 73 | 74 20 69 6e 66 65 63 74 |t agains|t infect|
|00002e10| 69 6f 75 73 20 64 69 73 | 65 61 73 65 2e 20 20 55 |ious dis|ease. U|
|00002e20| 6e 66 6f 72 74 75 6e 61 | 74 65 6c 79 2c 20 6d 6f |nfortuna|tely, mo|
|00002e30| 73 74 20 6f 66 20 74 68 | 65 0d 0a 6e 65 77 65 72 |st of th|e..newer|
|00002e40| 20 65 6e 74 72 69 65 73 | 20 61 72 65 20 76 65 72 | entries| are ver|
|00002e50| 79 20 65 78 70 65 6e 73 | 69 76 65 2c 20 65 76 65 |y expens|ive, eve|
|00002e60| 6e 20 74 68 6f 75 67 68 | 20 77 65 6c 6c 20 77 6f |n though| well wo|
|00002e70| 72 74 68 20 74 68 65 20 | 70 72 69 63 65 20 77 68 |rth the |price wh|
|00002e80| 65 6e 20 74 68 65 79 0d | 0a 61 72 65 20 72 65 61 |en they.|.are rea|
|00002e90| 6c 6c 79 20 6e 65 65 64 | 65 64 2e 20 20 4d 61 6e |lly need|ed. Man|
|00002ea0| 79 20 70 68 79 73 69 63 | 69 61 6e 73 20 70 72 65 |y physic|ians pre|
|00002eb0| 73 63 72 69 62 65 20 74 | 68 65 20 6e 65 77 65 72 |scribe t|he newer|
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|00002ef0| 74 68 61 74 20 63 61 6e | 20 62 65 20 6d 61 6e 61 |that can| be mana|
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|00002f10| 20 77 69 74 68 20 6f 6c | 64 65 72 2c 0d 0a 63 68 | with ol|der,..ch|
|00002f20| 65 61 70 65 72 20 64 72 | 75 67 73 2e 20 20 4c 65 |eaper dr|ugs. Le|
|00002f30| 74 74 69 6e 67 20 74 68 | 65 20 70 68 79 73 69 63 |tting th|e physic|
|00002f40| 69 61 6e 20 6b 6e 6f 77 | 20 74 68 65 20 63 6f 73 |ian know| the cos|
|00002f50| 74 20 6f 66 20 64 72 75 | 67 73 20 6d 61 79 20 68 |t of dru|gs may h|
|00002f60| 65 6c 70 20 72 65 64 75 | 63 65 0d 0a 6f 76 65 72 |elp redu|ce..over|
|00002f70| 61 6c 6c 20 65 78 70 65 | 6e 64 69 74 75 72 65 73 |all expe|nditures|
|00002f80| 2e 20 20 53 6f 6d 65 20 | 79 65 61 72 73 20 61 67 |. Some |years ag|
|00002f90| 6f 2c 20 49 20 73 75 67 | 67 65 73 74 65 64 20 66 |o, I sug|gested f|
|00002fa0| 61 63 65 74 69 6f 75 73 | 6c 79 20 74 68 61 74 20 |acetious|ly that |
|00002fb0| 77 65 20 70 61 79 20 6f | 75 72 0d 0a 72 65 73 69 |we pay o|ur..resi|
|00002fc0| 64 65 6e 74 73 20 24 38 | 30 2c 30 30 30 20 61 20 |dents $8|0,000 a |
|00002fd0| 79 65 61 72 20 62 75 74 | 20 6d 61 6b 65 20 74 68 |year but| make th|
|00002fe0| 65 6d 20 70 61 79 20 66 | 6f 72 20 74 68 65 20 64 |em pay f|or the d|
|00002ff0| 72 75 67 73 20 74 68 65 | 79 20 70 72 65 73 63 72 |rugs the|y prescr|
|00003000| 69 62 65 2e 20 20 57 68 | 65 6e 0d 0a 6d 6f 6e 65 |ibe. Wh|en..mone|
|00003010| 79 20 64 6f 65 73 20 6e | 6f 74 20 63 6f 6d 65 20 |y does n|ot come |
|00003020| 66 72 6f 6d 20 6f 6e 65 | 27 73 20 6f 77 6e 20 70 |from one|'s own p|
|00003030| 6f 63 6b 65 74 2c 20 74 | 68 65 72 65 20 69 73 20 |ocket, t|here is |
|00003040| 6c 69 74 74 6c 65 20 69 | 6e 63 65 6e 74 69 76 65 |little i|ncentive|
|00003050| 20 74 6f 0d 0a 73 61 76 | 65 2e 2d 2d 4c 2e 45 2e | to..sav|e.--L.E.|
|00003060| 20 48 6f 6c 6c 69 73 74 | 65 72 2c 20 4d 2e 44 2e | Hollist|er, M.D.|
|00003070| 0d 0a 24 55 6e 69 71 75 | 65 5f 49 44 7b 59 52 42 |..$Uniqu|e_ID{YRB|
|00003080| 30 39 38 30 34 7d 0d 0a | 24 54 69 74 6c 65 7b 41 |09804}..|$Title{A|
|00003090| 64 64 69 74 69 76 65 73 | 20 43 6f 6e 74 61 69 6e |dditives| Contain|
|000030a0| 65 64 20 69 6e 20 44 72 | 75 67 20 46 6f 72 6d 75 |ed in Dr|ug Formu|
|000030b0| 6c 61 74 69 6f 6e 73 20 | 4d 6f 73 74 20 46 72 65 |lations |Most Fre|
|000030c0| 71 75 65 6e 74 6c 79 20 | 50 72 65 73 63 72 69 62 |quently |Prescrib|
|000030d0| 65 64 20 69 6e 0d 0a 53 | 77 69 74 7a 65 72 6c 61 |ed in..S|witzerla|
|000030e0| 6e 64 7d 0d 0a 24 41 75 | 74 68 6f 72 7b 4b 6f 6c |nd}..$Au|thor{Kol|
|000030f0| 6c 79 2c 20 4d 0d 0a 50 | 65 63 6f 75 64 2c 20 41 |ly, M..P|ecoud, A|
|00003100| 0d 0a 46 72 65 69 2c 20 | 50 43 7d 0d 0a 24 41 66 |..Frei, |PC}..$Af|
|00003110| 66 69 6c 69 61 74 69 6f | 6e 7b 43 65 6e 74 72 65 |filiatio|n{Centre|
|00003120| 20 48 6f 73 70 69 74 61 | 6c 69 65 72 20 55 6e 69 | Hospita|lier Uni|
|00003130| 76 65 72 73 69 74 61 69 | 72 65 20 56 61 75 64 6f |versitai|re Vaudo|
|00003140| 69 73 2c 20 4c 61 75 73 | 61 6e 6e 65 2c 20 53 77 |is, Laus|anne, Sw|
|00003150| 69 74 7a 65 72 6c 61 6e | 64 7d 0d 0a 24 4a 6f 75 |itzerlan|d}..$Jou|
|00003160| 72 6e 61 6c 7b 41 6e 6e | 20 41 6c 6c 65 72 67 79 |rnal{Ann| Allergy|
|00003170| 7d 0d 0a 24 56 6f 6c 75 | 6d 65 7b 36 32 7d 0d 0a |}..$Volu|me{62}..|
|00003180| 24 50 61 67 65 7b 32 31 | 2d 32 35 7d 0d 0a 24 44 |$Page{21|-25}..$D|
|00003190| 61 74 65 7b 4a 61 6e 75 | 61 72 79 20 31 39 38 39 |ate{Janu|ary 1989|
|000031a0| 7d 0d 0a 24 59 42 56 6f | 6c 7b 31 39 39 30 20 59 |}..$YBVo|l{1990 Y|
|000031b0| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 44 72 75 67 |ear Book| of Drug|
|000031c0| 20 54 68 65 72 61 70 79 | 7d 0d 0a 24 43 68 61 70 | Therapy|}..$Chap|
|000031d0| 74 65 72 7b 31 2d 35 7d | 0d 0a 24 59 42 45 64 69 |ter{1-5}|..$YBEdi|
|000031e0| 74 6f 72 7b 44 72 73 2e | 20 48 6f 6c 6c 69 73 74 |tor{Drs.| Hollist|
|000031f0| 65 72 20 61 6e 64 20 4c | 61 73 61 67 6e 61 7d 0d |er and L|asagna}.|
|00003200| 0a 24 54 61 62 6c 65 7b | 54 61 62 6c 65 20 4f 6d |.$Table{|Table Om|
|00003210| 69 74 74 65 64 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |itted}..|$Comment|
|00003220| 61 74 6f 72 7b 4c 2e 20 | 20 4c 61 73 61 67 6e 61 |ator{L. | Lasagna|
|00003230| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|00003240| 69 67 68 74 20 28 63 29 | 20 59 65 61 72 62 6f 6f |ight (c)| Yearboo|
|00003250| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|00003260| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 39 30 |hers, In|c., 1990|
|00003270| 0d 0a 0d 0a 31 39 39 30 | 20 59 65 61 72 20 42 6f |....1990| Year Bo|
|00003280| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|00003290| 70 79 20 28 52 29 0d 0a | 0d 0a 43 68 61 70 74 65 |py (R)..|..Chapte|
|000032a0| 72 20 31 2d 2d 47 65 6e | 65 72 61 6c 20 49 6e 66 |r 1--Gen|eral Inf|
|000032b0| 6f 72 6d 61 74 69 6f 6e | 0d 0a 0d 0a 2d 2d 2d 2d |ormation|....----|
|000032c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000032d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000032e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000032f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003300| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 41 64 64 69 |--------|--..Addi|
|00003310| 74 69 76 65 73 20 43 6f | 6e 74 61 69 6e 65 64 20 |tives Co|ntained |
|00003320| 69 6e 20 44 72 75 67 20 | 46 6f 72 6d 75 6c 61 74 |in Drug |Formulat|
|00003330| 69 6f 6e 73 20 4d 6f 73 | 74 20 46 72 65 71 75 65 |ions Mos|t Freque|
|00003340| 6e 74 6c 79 20 50 72 65 | 73 63 72 69 62 65 64 20 |ntly Pre|scribed |
|00003350| 69 6e 0d 0a 53 77 69 74 | 7a 65 72 6c 61 6e 64 0d |in..Swit|zerland.|
|00003360| 0a 0d 0a 4b 6f 6c 6c 79 | 20 4d 3b 20 50 65 63 6f |...Kolly| M; Peco|
|00003370| 75 64 20 41 3b 20 46 72 | 65 69 20 50 43 0d 0a 28 |ud A; Fr|ei PC..(|
|00003380| 43 65 6e 74 72 65 20 48 | 6f 73 70 69 74 61 6c 69 |Centre H|ospitali|
|00003390| 65 72 20 55 6e 69 76 65 | 72 73 69 74 61 69 72 65 |er Unive|rsitaire|
|000033a0| 20 56 61 75 64 6f 69 73 | 2c 20 4c 61 75 73 61 6e | Vaudois|, Lausan|
|000033b0| 6e 65 2c 20 53 77 69 74 | 7a 65 72 6c 61 6e 64 29 |ne, Swit|zerland)|
|000033c0| 0d 0a 41 6e 6e 20 41 6c | 6c 65 72 67 79 20 36 32 |..Ann Al|lergy 62|
|000033d0| 3a 32 31 2d 32 35 2c 20 | 4a 61 6e 75 61 72 79 20 |:21-25, |January |
|000033e0| 31 39 38 39 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1989..--|--------|
|000033f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003400| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003410| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003420| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003430| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00003440| 0d 0a 0d 0a 20 20 20 20 | 20 54 68 65 20 70 72 6f |.... | The pro|
|00003450| 64 75 63 74 69 6f 6e 20 | 6f 66 20 70 68 61 72 6d |duction |of pharm|
|00003460| 61 63 65 75 74 69 63 61 | 6c 73 20 63 6f 6d 6d 6f |aceutica|ls commo|
|00003470| 6e 6c 79 20 69 6e 76 6f | 6c 76 65 73 20 74 68 65 |nly invo|lves the|
|00003480| 20 75 73 65 20 6f 66 20 | 73 75 63 68 0d 0a 61 64 | use of |such..ad|
|00003490| 64 69 74 69 76 65 73 20 | 61 73 20 64 79 65 73 2c |ditives |as dyes,|
|000034a0| 20 70 72 65 73 65 72 76 | 61 74 69 76 65 73 2c 20 | preserv|atives, |
|000034b0| 61 6e 74 69 6f 78 69 64 | 61 6e 74 73 2c 20 65 6d |antioxid|ants, em|
|000034c0| 75 6c 73 69 66 69 65 72 | 73 2c 20 73 74 61 62 69 |ulsifier|s, stabi|
|000034d0| 6c 69 7a 69 6e 67 0d 0a | 61 67 65 6e 74 73 2c 20 |lizing..|agents, |
|000034e0| 74 68 69 63 6b 65 6e 65 | 72 73 2c 20 73 77 65 65 |thickene|rs, swee|
|000034f0| 74 65 6e 65 72 73 2c 20 | 6f 72 20 66 6c 61 76 6f |teners, |or flavo|
|00003500| 72 73 2e 20 20 41 6e 79 | 20 6f 66 20 74 68 65 73 |rs. Any| of thes|
|00003510| 65 20 61 64 64 69 74 69 | 76 65 73 20 6d 61 79 20 |e additi|ves may |
|00003520| 69 6e 64 75 63 65 0d 0a | 69 64 69 6f 73 79 6e 63 |induce..|idiosync|
|00003530| 72 61 74 69 63 20 6f 72 | 20 70 73 65 75 64 6f 61 |ratic or| pseudoa|
|00003540| 6c 6c 65 72 67 69 63 20 | 72 65 61 63 74 69 6f 6e |llergic |reaction|
|00003550| 73 20 69 6e 20 73 75 73 | 63 65 70 74 69 62 6c 65 |s in sus|ceptible|
|00003560| 20 69 6e 64 69 76 69 64 | 75 61 6c 73 2c 20 65 76 | individ|uals, ev|
|00003570| 65 6e 0d 0a 74 68 6f 75 | 67 68 20 68 79 70 65 72 |en..thou|gh hyper|
|00003580| 73 65 6e 73 69 74 69 76 | 69 74 79 20 72 65 61 63 |sensitiv|ity reac|
|00003590| 74 69 6f 6e 73 20 68 61 | 76 65 20 62 65 65 6e 20 |tions ha|ve been |
|000035a0| 77 65 6c 6c 20 64 6f 63 | 75 6d 65 6e 74 65 64 20 |well doc|umented |
|000035b0| 6f 6e 6c 79 20 66 6f 72 | 20 70 61 72 61 62 65 6e |only for| paraben|
|000035c0| 73 0d 0a 61 6e 64 20 73 | 75 6c 66 69 74 65 73 2e |s..and s|ulfites.|
|000035d0| 20 20 54 68 65 20 61 63 | 74 75 61 6c 20 6e 75 6d | The ac|tual num|
|000035e0| 62 65 72 20 61 6e 64 20 | 74 79 70 65 73 20 6f 66 |ber and |types of|
|000035f0| 20 63 68 65 6d 69 63 61 | 6c 73 20 61 64 64 65 64 | chemica|ls added|
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|00003640| 6c 20 63 68 65 6d 69 63 | 61 6c 73 20 61 64 64 65 |l chemic|als adde|
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|00003670| 63 6f 6d 70 6f 75 6e 64 | 73 20 63 6f 6d 6d 6f 6e |compound|s common|
|00003680| 6c 79 20 70 72 65 73 63 | 72 69 62 65 64 20 69 6e |ly presc|ribed in|
|00003690| 20 53 77 69 74 7a 65 72 | 6c 61 6e 64 20 62 79 20 | Switzer|land by |
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|00003920| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
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|00003950| 61 72 65 20 6e 6f 74 20 | 74 72 69 76 69 61 6c 20 |are not |trivial |
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|000039f0| 65 66 66 65 63 74 73 2e | 20 20 44 69 66 66 65 72 |effects.| Differ|
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|00003ae0| 72 73 20 74 68 61 74 20 | 74 68 65 20 70 6f 73 73 |rs that |the poss|
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|00003b60| 65 72 73 3f 2d 2d 4c 2e | 20 4c 61 73 61 67 6e 61 |ers?--L.| Lasagna|
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|00003c10| 69 6c 69 61 74 69 6f 6e | 7b 55 6e 69 76 20 6f 66 |iliation|{Univ of|
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|00003c40| 20 61 6e 64 20 48 65 61 | 6c 74 68 20 44 65 70 74 | and Hea|lth Dept|
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|00003c60| 6f 75 72 6e 61 6c 7b 4a | 20 43 6c 69 6e 20 50 68 |ournal{J| Clin Ph|
|00003c70| 61 72 6d 61 63 6f 6c 7d | 0d 0a 24 56 6f 6c 75 6d |armacol}|..$Volum|
|00003c80| 65 7b 32 38 7d 0d 0a 24 | 50 61 67 65 7b 31 30 37 |e{28}..$|Page{107|
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|00003cb0| 30 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 44 |0 Year B|ook of D|
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|00003cd0| 68 61 70 74 65 72 7b 31 | 2d 36 7d 0d 0a 24 59 42 |hapter{1|-6}..$YB|
|00003ce0| 45 64 69 74 6f 72 7b 44 | 72 73 2e 20 48 6f 6c 6c |Editor{D|rs. Holl|
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|00003d10| 20 4f 6d 69 74 74 65 64 | 7d 0d 0a 24 43 6f 6d 6d | Omitted|}..$Comm|
|00003d20| 65 6e 74 61 74 6f 72 7b | 4c 2e 20 20 4c 61 73 61 |entator{|L. Lasa|
|00003d30| 67 6e 61 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |gna, M.D|.}....Co|
|00003d40| 70 79 72 69 67 68 74 20 | 28 63 29 20 59 65 61 72 |pyright |(c) Year|
|00003d50| 62 6f 6f 6b 20 4d 65 64 | 69 63 61 6c 20 50 75 62 |book Med|ical Pub|
|00003d60| 6c 69 73 68 65 72 73 2c | 20 49 6e 63 2e 2c 20 31 |lishers,| Inc., 1|
|00003d70| 39 39 30 0d 0a 0d 0a 31 | 39 39 30 20 59 65 61 72 |990....1|990 Year|
|00003d80| 20 42 6f 6f 6b 20 6f 66 | 20 44 72 75 67 20 54 68 | Book of| Drug Th|
|00003d90| 65 72 61 70 79 20 28 52 | 29 0d 0a 0d 0a 43 68 61 |erapy (R|)....Cha|
|00003da0| 70 74 65 72 20 31 2d 2d | 47 65 6e 65 72 61 6c 20 |pter 1--|General |
|00003db0| 49 6e 66 6f 72 6d 61 74 | 69 6f 6e 0d 0a 0d 0a 2d |Informat|ion....-|
|00003dc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003dd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003de0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003df0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 57 |--------|-----..W|
|00003e10| 6f 72 6c 64 77 69 64 65 | 20 56 61 72 69 61 74 69 |orldwide| Variati|
|00003e20| 6f 6e 20 69 6e 20 43 68 | 6c 6f 72 61 6d 70 68 65 |on in Ch|loramphe|
|00003e30| 6e 69 63 6f 6c 20 55 74 | 69 6c 69 7a 61 74 69 6f |nicol Ut|ilizatio|
|00003e40| 6e 3a 20 20 53 68 6f 75 | 6c 64 20 49 74 20 43 61 |n: Shou|ld It Ca|
|00003e50| 75 73 65 20 43 6f 6e 63 | 65 72 6e 3f 0d 0a 0d 0a |use Conc|ern?....|
|00003e60| 4b 75 6d 61 6e 61 20 43 | 52 3b 20 4c 69 20 4b 59 |Kumana C|R; Li KY|
|00003e70| 3b 20 43 68 61 75 20 50 | 59 0d 0a 28 55 6e 69 76 |; Chau P|Y..(Univ|
|00003e80| 20 6f 66 20 48 6f 6e 67 | 20 4b 6f 6e 67 3b 20 51 | of Hong| Kong; Q|
|00003e90| 75 65 65 6e 20 4d 61 72 | 79 20 48 6f 73 70 3b 20 |ueen Mar|y Hosp; |
|00003ea0| 4d 65 64 20 61 6e 64 20 | 48 65 61 6c 74 68 20 44 |Med and |Health D|
|00003eb0| 65 70 74 2c 20 48 6f 6e | 67 20 4b 6f 6e 67 29 0d |ept, Hon|g Kong).|
|00003ec0| 0a 4a 20 43 6c 69 6e 20 | 50 68 61 72 6d 61 63 6f |.J Clin |Pharmaco|
|00003ed0| 6c 20 32 38 3a 31 30 37 | 31 2d 31 30 37 35 2c 20 |l 28:107|1-1075, |
|00003ee0| 31 39 38 38 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1988..--|--------|
|00003ef0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f30| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00003f40| 0d 0a 0d 0a 20 20 20 20 | 20 43 68 6c 6f 72 61 6d |.... | Chloram|
|00003f50| 70 68 65 6e 69 63 6f 6c | 20 74 68 65 72 61 70 79 |phenicol| therapy|
|00003f60| 20 68 61 73 20 62 65 65 | 6e 20 72 65 73 74 72 69 | has bee|n restri|
|00003f70| 63 74 65 64 20 74 6f 20 | 61 20 6c 69 6d 69 74 65 |cted to |a limite|
|00003f80| 64 20 6e 75 6d 62 65 72 | 20 6f 66 0d 0a 69 6e 64 |d number| of..ind|
|00003f90| 69 63 61 74 69 6f 6e 73 | 20 62 65 63 61 75 73 65 |ications| because|
|00003fa0| 20 69 74 20 63 61 6e 20 | 6c 65 61 64 20 74 6f 20 | it can |lead to |
|00003fb0| 61 70 6c 61 73 74 69 63 | 20 61 6e 65 6d 69 61 2e |aplastic| anemia.|
|00003fc0| 20 20 48 6f 77 65 76 65 | 72 2c 20 69 6e 20 48 6f | Howeve|r, in Ho|
|00003fd0| 6e 67 20 4b 6f 6e 67 0d | 0a 6c 61 72 67 65 20 61 |ng Kong.|.large a|
|00003fe0| 6d 6f 75 6e 74 73 20 6f | 66 20 63 68 6c 6f 72 61 |mounts o|f chlora|
|00003ff0| 6d 70 68 65 6e 69 63 6f | 6c 20 61 72 65 20 75 73 |mphenico|l are us|
|00004000| 65 64 20 61 73 20 61 6e | 74 69 6d 69 63 72 6f 62 |ed as an|timicrob|
|00004010| 69 61 6c 73 20 66 6f 72 | 20 62 6f 74 68 20 63 68 |ials for| both ch|
|00004020| 69 6c 64 72 65 6e 0d 0a | 61 6e 64 20 61 64 75 6c |ildren..|and adul|
|00004030| 74 73 2e 20 20 54 68 65 | 72 65 66 6f 72 65 20 74 |ts. The|refore t|
|00004040| 68 65 20 65 78 74 65 6e | 74 20 74 6f 20 77 68 69 |he exten|t to whi|
|00004050| 63 68 20 63 68 6c 6f 72 | 61 6d 70 68 65 6e 69 63 |ch chlor|amphenic|
|00004060| 6f 6c 20 63 6f 6e 74 72 | 69 62 75 74 65 73 20 74 |ol contr|ibutes t|
|00004070| 6f 20 74 68 65 0d 0a 6c | 6f 63 61 6c 20 69 6e 63 |o the..l|ocal inc|
|00004080| 69 64 65 6e 63 65 20 6f | 66 20 61 70 6c 61 73 74 |idence o|f aplast|
|00004090| 69 63 20 61 6e 65 6d 69 | 61 20 77 61 73 20 73 74 |ic anemi|a was st|
|000040a0| 75 64 69 65 64 2e 0d 0a | 20 20 20 20 20 50 65 72 |udied...| Per|
|000040b0| 20 63 61 70 69 74 61 20 | 73 61 6c 65 73 20 6f 66 | capita |sales of|
|000040c0| 20 63 68 6c 6f 72 61 6d | 70 68 65 6e 69 63 6f 6c | chloram|phenicol|
|000040d0| 20 69 6e 20 48 6f 6e 67 | 20 4b 6f 6e 67 20 77 65 | in Hong| Kong we|
|000040e0| 72 65 20 32 32 2d 34 34 | 32 20 74 69 6d 65 73 0d |re 22-44|2 times.|
|000040f0| 0a 67 72 65 61 74 65 72 | 20 74 68 61 6e 20 69 6e |.greater| than in|
|00004100| 20 73 65 76 65 72 61 6c | 20 77 65 73 74 65 72 6e | several| western|
|00004110| 20 63 6f 75 6e 74 72 69 | 65 73 20 61 6e 64 20 41 | countri|es and A|
|00004120| 75 73 74 72 61 6c 69 61 | 20 28 74 61 62 6c 65 29 |ustralia| (table)|
|00004130| 2e 20 20 44 65 73 70 69 | 74 65 20 73 75 63 68 0d |. Despi|te such.|
|00004140| 0a 65 78 70 6f 73 75 72 | 65 20 74 68 65 20 63 65 |.exposur|e the ce|
|00004150| 72 74 69 66 69 65 64 20 | 64 65 61 74 68 20 72 61 |rtified |death ra|
|00004160| 74 65 20 66 72 6f 6d 20 | 61 70 6c 61 73 74 69 63 |te from |aplastic|
|00004170| 20 61 6e 65 6d 69 61 20 | 28 72 65 67 61 72 64 6c | anemia |(regardl|
|00004180| 65 73 73 20 6f 66 0d 0a | 69 64 65 6e 74 69 66 69 |ess of..|identifi|
|00004190| 61 62 6c 65 20 63 61 75 | 73 65 29 20 69 6e 20 48 |able cau|se) in H|
|000041a0| 6f 6e 67 20 4b 6f 6e 67 | 20 77 61 73 20 6f 6e 6c |ong Kong| was onl|
|000041b0| 79 20 30 2e 34 2f 31 2c | 30 30 30 20 64 65 61 74 |y 0.4/1,|000 deat|
|000041c0| 68 73 2c 20 63 6f 6d 70 | 61 72 65 64 20 77 69 74 |hs, comp|ared wit|
|000041d0| 68 0d 0a 31 2e 30 2f 31 | 2c 30 30 30 20 64 65 61 |h..1.0/1|,000 dea|
|000041e0| 74 68 73 20 69 6e 20 45 | 6e 67 6c 61 6e 64 20 61 |ths in E|ngland a|
|000041f0| 6e 64 20 57 61 6c 65 73 | 2e 20 20 4e 6f 20 6f 74 |nd Wales|. No ot|
|00004200| 68 65 72 20 65 76 69 64 | 65 6e 63 65 20 77 61 73 |her evid|ence was|
|00004210| 20 66 6f 75 6e 64 20 74 | 6f 0d 0a 69 6e 64 69 63 | found t|o..indic|
|00004220| 61 74 65 20 74 68 61 74 | 20 48 6f 6e 67 20 4b 6f |ate that| Hong Ko|
|00004230| 6e 67 20 72 65 73 69 64 | 65 6e 74 73 20 65 78 70 |ng resid|ents exp|
|00004240| 65 72 69 65 6e 63 65 64 | 20 61 6e 20 65 78 63 65 |erienced| an exce|
|00004250| 73 73 69 76 65 20 69 6e | 63 69 64 65 6e 63 65 20 |ssive in|cidence |
|00004260| 6f 66 0d 0a 61 70 6c 61 | 73 74 69 63 20 61 6e 65 |of..apla|stic ane|
|00004270| 6d 69 61 2e 0d 0a 20 20 | 20 20 20 41 6c 74 68 6f |mia... | Altho|
|00004280| 75 67 68 20 74 68 65 20 | 61 6d 6f 75 6e 74 73 20 |ugh the |amounts |
|00004290| 6f 66 20 63 68 6c 6f 72 | 61 6d 70 68 65 6e 69 63 |of chlor|amphenic|
|000042a0| 6f 6c 20 73 6f 6c 64 20 | 69 6e 20 48 6f 6e 67 20 |ol sold |in Hong |
|000042b0| 4b 6f 6e 67 20 61 72 65 | 20 68 69 67 68 2c 20 74 |Kong are| high, t|
|000042c0| 68 65 0d 0a 65 78 74 65 | 6e 74 20 74 6f 20 77 68 |he..exte|nt to wh|
|000042d0| 69 63 68 20 73 75 63 68 | 20 77 69 64 65 73 70 72 |ich such| widespr|
|000042e0| 65 61 64 20 63 6f 6e 73 | 75 6d 70 74 69 6f 6e 20 |ead cons|umption |
|000042f0| 63 6f 6e 74 72 69 62 75 | 74 65 73 20 74 6f 20 61 |contribu|tes to a|
|00004300| 70 6c 61 73 74 69 63 20 | 61 6e 65 6d 69 61 0d 0a |plastic |anemia..|
|00004310| 61 70 70 65 61 72 73 20 | 74 6f 20 62 65 20 6c 6f |appears |to be lo|
|00004320| 77 65 72 20 74 68 61 6e | 20 65 78 70 65 63 74 65 |wer than| expecte|
|00004330| 64 2e 20 20 42 65 63 61 | 75 73 65 20 6f 66 20 74 |d. Beca|use of t|
|00004340| 68 65 20 61 6c 6c 65 67 | 65 64 20 68 69 67 68 20 |he alleg|ed high |
|00004350| 72 69 73 6b 20 6f 66 0d | 0a 63 68 6c 6f 72 61 6d |risk of.|.chloram|
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|00005e50| 65 7b 33 39 7d 0d 0a 24 | 50 61 67 65 7b 32 30 31 |e{39}..$|Page{201|
|00005e60| 2d 32 30 36 7d 0d 0a 24 | 44 61 74 65 7b 46 65 62 |-206}..$|Date{Feb|
|00005e70| 72 75 61 72 79 20 31 39 | 38 39 7d 0d 0a 24 59 42 |ruary 19|89}..$YB|
|00005e80| 56 6f 6c 7b 31 39 39 30 | 20 59 65 61 72 20 42 6f |Vol{1990| Year Bo|
|00005e90| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|00005ea0| 70 79 7d 0d 0a 24 43 68 | 61 70 74 65 72 7b 31 2d |py}..$Ch|apter{1-|
|00005eb0| 39 7d 0d 0a 24 59 42 45 | 64 69 74 6f 72 7b 44 72 |9}..$YBE|ditor{Dr|
|00005ec0| 73 2e 20 48 6f 6c 6c 69 | 73 74 65 72 20 61 6e 64 |s. Holli|ster and|
|00005ed0| 20 4c 61 73 61 67 6e 61 | 7d 0d 0a 24 54 61 62 6c | Lasagna|}..$Tabl|
|00005ee0| 65 7b 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |e{}..$Co|mmentato|
|00005ef0| 72 7b 4c 2e 20 20 4c 61 | 73 61 67 6e 61 2c 20 4d |r{L. La|sagna, M|
|00005f00| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|00005f10| 74 20 28 63 29 20 59 65 | 61 72 62 6f 6f 6b 20 4d |t (c) Ye|arbook M|
|00005f20| 65 64 69 63 61 6c 20 50 | 75 62 6c 69 73 68 65 72 |edical P|ublisher|
|00005f30| 73 2c 20 49 6e 63 2e 2c | 20 31 39 39 30 0d 0a 0d |s, Inc.,| 1990...|
|00005f40| 0a 31 39 39 30 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1990 Ye|ar Book |
|00005f50| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 20 |of Drug |Therapy |
|00005f60| 28 52 29 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 31 |(R)....C|hapter 1|
|00005f70| 2d 2d 47 65 6e 65 72 61 | 6c 20 49 6e 66 6f 72 6d |--Genera|l Inform|
|00005f80| 61 74 69 6f 6e 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |ation...|.-------|
|00005f90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fa0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fd0| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 43 6c 69 6e 69 63 61 |-------.|.Clinica|
|00005fe0| 6c 20 53 61 66 65 74 79 | 20 6f 66 20 41 73 70 61 |l Safety| of Aspa|
|00005ff0| 72 74 61 6d 65 0d 0a 0d | 0a 59 6f 73 74 20 44 41 |rtame...|.Yost DA|
|00006000| 0d 0a 28 55 6e 69 76 20 | 6f 66 20 41 72 69 7a 6f |..(Univ |of Arizo|
|00006010| 6e 61 2c 20 54 75 63 73 | 6f 6e 29 0d 0a 41 6d 20 |na, Tucs|on)..Am |
|00006020| 46 61 6d 20 50 68 79 73 | 69 63 69 61 6e 20 33 39 |Fam Phys|ician 39|
|00006030| 3a 32 30 31 2d 32 30 36 | 2c 20 46 65 62 72 75 61 |:201-206|, Februa|
|00006040| 72 79 20 31 39 38 39 0d | 0a 2d 2d 2d 2d 2d 2d 2d |ry 1989.|.-------|
|00006050| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006060| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006070| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006080| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006090| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 0d 0a 41 62 73 74 72 |-------.|...Abstr|
|000060a0| 61 63 74 0d 0a 0d 0a 20 | 20 20 20 20 49 74 20 69 |act.... | It i|
|000060b0| 73 20 65 73 74 69 6d 61 | 74 65 64 20 74 68 61 74 |s estima|ted that|
|000060c0| 20 6d 6f 72 65 20 74 68 | 61 6e 20 31 30 30 20 6d | more th|an 100 m|
|000060d0| 69 6c 6c 69 6f 6e 20 70 | 65 72 73 6f 6e 73 20 69 |illion p|ersons i|
|000060e0| 6e 20 74 68 65 20 55 6e | 69 74 65 64 20 53 74 61 |n the Un|ited Sta|
|000060f0| 74 65 73 0d 0a 72 6f 75 | 74 69 6e 65 6c 79 20 69 |tes..rou|tinely i|
|00006100| 6e 67 65 73 74 20 74 68 | 65 20 6c 6f 77 2d 63 61 |ngest th|e low-ca|
|00006110| 6c 6f 72 69 65 20 6e 75 | 74 72 69 74 69 76 65 20 |lorie nu|tritive |
|00006120| 73 77 65 65 74 65 6e 65 | 72 20 61 73 70 61 72 74 |sweetene|r aspart|
|00006130| 61 6d 65 20 61 73 20 61 | 20 73 75 67 61 72 0d 0a |ame as a| sugar..|
|00006140| 72 65 70 6c 61 63 65 6d | 65 6e 74 2e 20 20 48 6f |replacem|ent. Ho|
|00006150| 77 65 76 65 72 2c 20 6d | 61 6e 79 20 68 61 76 65 |wever, m|any have|
|00006160| 20 71 75 65 73 74 69 6f | 6e 65 64 20 69 74 73 20 | questio|ned its |
|00006170| 73 61 66 65 74 79 20 77 | 69 74 68 20 72 65 73 70 |safety w|ith resp|
|00006180| 65 63 74 20 74 6f 20 74 | 68 65 0d 0a 70 6f 74 65 |ect to t|he..pote|
|00006190| 6e 74 69 61 6c 20 61 64 | 76 65 72 73 65 20 65 66 |ntial ad|verse ef|
|000061a0| 66 65 63 74 73 20 6f 66 | 20 69 74 73 20 6d 65 74 |fects of| its met|
|000061b0| 61 62 6f 6c 69 74 65 73 | 2e 0d 0a 20 20 20 20 20 |abolites|... |
|000061c0| 41 73 70 61 72 74 61 6d | 65 20 69 73 20 62 72 6f |Aspartam|e is bro|
|000061d0| 6b 65 6e 20 64 6f 77 6e | 20 62 79 20 69 6e 74 65 |ken down| by inte|
|000061e0| 73 74 69 6e 61 6c 20 65 | 73 74 65 72 61 73 65 73 |stinal e|sterases|
|000061f0| 20 61 6e 64 20 64 69 70 | 65 70 74 69 64 61 73 65 | and dip|eptidase|
|00006200| 73 20 69 6e 74 6f 0d 0a | 74 68 65 20 6d 65 74 61 |s into..|the meta|
|00006210| 62 6f 6c 69 74 65 73 20 | 61 73 70 61 72 74 61 74 |bolites |aspartat|
|00006220| 65 2c 20 6d 65 74 68 61 | 6e 6f 6c 2c 20 61 6e 64 |e, metha|nol, and|
|00006230| 20 70 68 65 6e 79 6c 61 | 6c 61 6e 69 6e 65 2c 20 | phenyla|lanine, |
|00006240| 77 68 69 63 68 20 65 6e | 74 65 72 20 6e 6f 72 6d |which en|ter norm|
|00006250| 61 6c 0d 0a 6d 65 74 61 | 62 6f 6c 69 63 20 70 61 |al..meta|bolic pa|
|00006260| 74 68 77 61 79 73 2e 20 | 20 45 78 70 6f 73 75 72 |thways. | Exposur|
|00006270| 65 20 74 6f 20 68 69 67 | 68 20 6c 65 76 65 6c 73 |e to hig|h levels|
|00006280| 20 6f 66 20 61 6e 79 20 | 6f 66 20 74 68 65 73 65 | of any |of these|
|00006290| 20 6d 65 74 61 62 6f 6c | 69 74 65 73 20 69 73 0d | metabol|ites is.|
|000062a0| 0a 65 78 74 72 65 6d 65 | 6c 79 20 75 6e 6c 69 6b |.extreme|ly unlik|
|000062b0| 65 6c 79 2e 20 20 45 76 | 65 6e 20 6c 61 72 67 65 |ely. Ev|en large|
|000062c0| 20 64 6f 73 65 73 20 6f | 66 20 61 73 70 61 72 74 | doses o|f aspart|
|000062d0| 61 6d 65 20 63 6f 6e 73 | 75 6d 65 64 20 62 79 20 |ame cons|umed by |
|000062e0| 70 65 72 73 6f 6e 73 20 | 77 68 6f 20 61 72 65 0d |persons |who are.|
|000062f0| 0a 68 6f 6d 6f 7a 79 67 | 6f 75 73 20 66 6f 72 20 |.homozyg|ous for |
|00006300| 70 68 65 6e 79 6c 6b 65 | 74 6f 6e 75 72 69 61 20 |phenylke|tonuria |
|00006310| 28 50 4b 55 29 20 68 61 | 76 65 20 66 61 69 6c 65 |(PKU) ha|ve faile|
|00006320| 64 20 74 6f 20 70 72 6f | 64 75 63 65 20 74 6f 78 |d to pro|duce tox|
|00006330| 69 63 0d 0a 70 68 65 6e | 79 6c 61 6c 61 6e 69 6e |ic..phen|ylalanin|
|00006340| 65 20 6c 65 76 65 6c 73 | 2e 20 20 49 6e 74 61 63 |e levels|. Intac|
|00006350| 74 20 61 73 70 61 72 74 | 61 6d 65 20 6d 6f 6c 65 |t aspart|ame mole|
|00006360| 63 75 6c 65 73 20 61 72 | 65 20 6e 6f 74 20 61 62 |cules ar|e not ab|
|00006370| 73 6f 72 62 65 64 20 69 | 6e 74 6f 20 74 68 65 0d |sorbed i|nto the.|
|00006380| 0a 62 6c 6f 6f 64 2e 20 | 20 50 68 65 6e 79 6c 61 |.blood. | Phenyla|
|00006390| 6c 61 6e 69 6e 65 20 63 | 72 6f 73 73 65 73 20 74 |lanine c|rosses t|
|000063a0| 68 65 20 70 6c 61 63 65 | 6e 74 61 2c 20 62 75 74 |he place|nta, but|
|000063b0| 20 6d 61 74 65 72 6e 61 | 6c 20 70 68 65 6e 79 6c | materna|l phenyl|
|000063c0| 61 6c 61 6e 69 6e 65 20 | 6c 65 76 65 6c 73 0d 0a |alanine |levels..|
|000063d0| 61 66 74 65 72 20 61 73 | 70 61 72 74 61 6d 65 20 |after as|partame |
|000063e0| 64 6f 73 69 6e 67 20 68 | 61 76 65 20 63 6f 6e 73 |dosing h|ave cons|
|000063f0| 69 73 74 65 6e 74 6c 79 | 20 72 65 6d 61 69 6e 65 |istently| remaine|
+--------+-------------------------+-------------------------+--------+--------+
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